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  1. The mean duration of effect as measured by a 15 increase in pefr over the pretreatment value was greater tretinoin cream 0.05 than 3 hours.

  2. These doses are 10 and 20 times the maximum human systemic dose, when adjusted for total body surface area. See a picture of Wrinkles and learn more about the health topic. Let your skin return to normal tretinoin cream before you begin the treatment again.